Cyclophosphamide in Treatment of Nephrotic Syndrome

SIR,-Your leading article on this subject (4 December, p. 613) was no doubt justified by the recent reports you quoted. There was, however, one outstanding flaw in your review which was to my mind almost criminally negligent. You did not draw attention to the fact that it was in the cases treated in an ambulant manner that paraplegia developed during treatment. I feel that you should draw attention to this and that any one treating tuberculosis of the spine in the ambulant manner for the first time should confine his experiment to patients with the disease located below the termination of the dura and particularly not in the dangerous vertebrae, dorsal 4-8.-I am, etc.,